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| Mycobacterium tuberculosis bacteria using acid-fast Ziehl-Neelsen stain ( CDC Public Health Library) |
Reminders:
Tuberculosis (TB) is a bacterial infection that can affect almost any part of the body but most commonly affects the lungs. TB found in the lungs is called pulmonary tuberculosis. TB found in other parts of the body is called extrapulmonary tuberculosis. Examples of extrapulmonary TB are lymph node TB, abdominal TB, tuberculous meningitis, TB of bones and joints and genitourinary TB. These forms of tuberculosis can cause many different symptoms and mimic various other diseases.
Symptoms:Tuberculosis seldom begins with striking signs or symptoms, and may progress for weeks or even months before suspicion is aroused.
Symptoms can include:
Transmission:Pulmonary TB is transmitted from person to person via droplets from the throat and lungs of an infected person. An infected person expels droplets of moisture containing TB germs from their lungs when they cough, sneeze, laugh or speak. You can become exposed to TB by inhaling these droplets. Occasionally, cattle can transmit TB to humans through the milk of infected animals however this is extremely rare due to milk pasteurisation and extensive testing for bovine TB in cattle. Extrapulmonary TB results from dissemination of TB from the lungs through the blood stream or via lymphatic channels.
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| X-ray of a patient diagnosed with advanced bilateral pulmonary tuberculosis.( CDC Public Health Library ) |
Treatment:In many cases, TB can be treated with a six-month course of anti-tuberculosis medications including Isoniazid (INAH), Rifampicin, Ethambutol and Pyrazinamide. Uncomplicated tuberculosis responds readily to treatment in the early stages, but response may be slower if the disease is advanced. Treatment is longer and more complicated if there is drug resistance or reactions to the major drugs. Alternative treatment with second-line drugs requires a longer course of treatment (which can be up to two years or more in complicated drug-resistant cases).
If left undiagnosed and untreated, TB can be a very serious disease. However, provided anti- tuberculosis medications are taken exactly as prescribed, patients with active TB disease can be cured. Once treatment is completed, it is unusual for the disease to reactivate with most patients remaining free of TB disease for the rest of their life.
The majority of the population who are infected by inhaling the TB germ (around 80 to 90%) are able to fight the TB infection through their immune system and do not become sick with the disease. Instead, the TB bacteria lays dormant within their body for years, and their body develops immunity to fight off further infection. However, if an infected person’s immune system is weakened (such as during a HIV infection), the chances of becoming sick with TB disease are greater. Only five to ten per cent of people who are infected with TB bacteria become sick with active TB disease with potential for infectiousness to others at some time during their life. Therefore, only a small percentage of the population infected with the TB germ (less than 20%) goes on to develop active TB disease. Left untreated, each person with active infectious TB disease will infect between 10 and 15 people every year (on average). This is why early diagnosis and effective treatment of TB remain the best preventive measures for controlling TB.
The majority of the population who are infected by inhaling the TB germ (around 80 to 90%) are able to fight the TB infection through their immune system and do not become sick with the disease. Instead, the TB bacteria lays dormant within their body for years, and their body develops immunity to fight off further infection. However, if an infected person’s immune system is weakened (such as during a HIV infection), the chances of becoming sick with TB disease are greater. Only five to ten per cent of people who are infected with TB bacteria become sick with active TB disease with potential for infectiousness to others at some time during their life. Therefore, only a small percentage of the population infected with the TB germ (less than 20%) goes on to develop active TB disease. Left untreated, each person with active infectious TB disease will infect between 10 and 15 people every year (on average). This is why early diagnosis and effective treatment of TB remain the best preventive measures for controlling TB.
Reference: Queensland Health Web Site




